This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Supplement Article

Guideline 16: Combining Medications in Older Patients


Published: January 1, 2004

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

The experts recommended close monitoring for side effects when using the combinations listed in the table below. More than a quarter of the experts considered the following combinations to be contraindicated: clozapine + carbamazepine (rated as contraindicated by 39% of the experts), ziprasidone + a tricyclic antidepressant (TCA) (rated as contraindicated by 26%), and a low-potency conventional antipsychotic + fluoxetine (rated as contraindicated by 27%). Certain combinations of medications caused the experts more concern (e.g., drugs that are potent inhibitors of CYP drug-metabolizing enzymes and thus have increased potential to cause drug-drug interactions).’ ‹

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 65

Quick Links: