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Educational Activity

Initial Treatment Approaches for Patients With Major Depressive Disorder

George I. Papakostas

Published: June 18, 2009

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

Article Abstract

The mainstay of treatment for major depressive disorder has been antidepressant monotherapy or, preferably, the combination of psychotherapy and antidepressants. However, combining antidepressant agents as a first-line treatment is an emerging area of research that is not yet widely practiced. Factors for choosing an antidepressant include indication, efficacy, tolerability, and safety. Patient preference and treatment history should also be considered when deciding which initial treatment approach is appropriate.

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