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Despite recent advances in the understanding and management of depression and anxiety, these disorders remain a challenge for the practicing clinician. As many as one third of patients with depression do not respond to monotherapy with an antidepressant.1Thehuman and economic impact of depression remains high; unipolar depression is expected tobecome the most common cause of disability in developed countries within the next severalyears.2‘ ‹


J Clin Psychiatry 2005;66(suppl 8):3-4

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