This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Hormonal Side Effects in Women: Typical Versus Atypical Antipsychotic Treatment

Ruth A. Dickson, MD, FRCPC; Mary V. Seeman, MDCM, FRCPC, FACP; and Bernard Corenblum, MD, FRCPC

Published: March 31, 2000

Article Abstract

Neuroleptic-induced hyperprolactinemia can cause menstrual disorders, impaired fertility, galactorrhea,and sexual dysfunction, as well as hypoestrogenism secondary to disruption of the hypothalamic-pituitary-ovarian axis. The development of the prolactin-sparing atypical antipsychotic drugs offersprevention and resolution of these adverse reactions. Thus far, this property of the newmedications has received insufficient clinical attention. The authors use case vignettes to discuss assessmentand management of clinical situations that arise as a result of antipsychotic-induced endocrinechanges.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 61

Quick Links: Populations , Women

Sign-up to stay
up-to-date today!


Already registered? Sign In

Case Report

Safety and Tolerability of Concomitant Intranasal Esketamine Treatment With Irreversible, Nonselective MAOIs: A Case Series

Three cases suggest that concomitant use of intranasal esketamine with an irreversible, nonselective MAOI is safe in...