This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Brainstorms

Brainstorms: Anticonvulsants as Anxiolytics, Part 2: Pregabalin and Gabapentin as α2δ Ligands at Voltage-Gated Calcium Channels

Stephen M. Stahl, MD, PhD

Published: April 1, 2004

Article Abstract

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Activation of fear circuits is a leading hypothesis for explaining symptoms in anxiety disorders,1-3 and returning neurotransmission in these circuits to a more normal pattern may reduce certain symptoms.4 For example, anticonvulsants may theoretically reduce seizures by decreasing excessive output from epileptic neurons, and could, by analogy, reduce symptoms of anxiety if these agents were also able to decrease neuronal activation within fear circuits.1-4


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 65

Quick Links: Epilepsy , Neurodevelopmental

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Case Report

Safety and Tolerability of Concomitant Intranasal Esketamine Treatment With Irreversible, Nonselective MAOIs: A Case Series

Three cases suggest that concomitant use of intranasal esketamine with an irreversible, nonselective MAOI is safe in...

Read More...