This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letters to the Editor

Is Antipsychotic Drug-Induced Weight Gain Associated With a Favorable Clinical Response?

J. Steven Lamberti

Published: September 30, 2000

Article Abstract

Letter to the Editor

Sir: I am writing to comment on Dr. Ganguli’s recent article on weight gain associated with antipsychotic drugs. The article stated that reports by Leadbetter et al. and Lamberti et al. differed as to whether clozapine-induced weight gain correlated with clinical improvement among patients with schizophrenia. As a point of clarification, our findings were consistent with those of Leadbetter et al. We found a trend for Brief Psychiatric Rating Scale score changes to correlate inversely with amount of weight gained such that lower (improved) scores were associated with larger gains. Most recently, this issue was examined in a large group of patients with schizophrenia or related disorders receiving treatment with olanzapine, risperidone, or haloperidol. Analyzing data from a total of 2266 patients, weight gain was found to be associated with a favorable clinical response for each of the 3 drugs.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 61

Quick Links: Neurologic and Neurocognitive , Neurology

Sign-up to stay
up-to-date today!

SUBSCRIBE

Already registered? Sign In

Original Research

Frontothalamic Circuit Abnormalities in Patients With Bipolar Depression and Suicide Attempts

To identify potential markers for suicide risk, this fMRI study looked at neural activity in bipolar depression...

Read More...