Ribavirin May Be an Important Factor in IFN-Induced Neuropsychiatric Effects
Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.
Sir: The recent article by Kraus et al.1 is of considerable interest since interferon (IFN)-induced neuropsychiatric effects are highly prevalent, but minimally studied, in prospectively designed reports. As reported previously, IFN treatment of chronic hepatitis C resulted in a significant increase in depression, anxiety, and irritability/hostility scores. These neuropsychiatric disturbances frequently necessitate dose reduction and/ or treatment discontinuation, an approach that may compromise the treatment of hepatitis C virus (HCV).
J Clin Psychiatry 2004;65(4):581-581