This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letters to the Editor

Risperidone May Worsen Fluoxetine-Treated OCD

Article Abstract

Sir: Several recent studies have suggested that risperidone may usefully augment serotonin reuptake inhibitor (SRI) therapy in refractory obsessive-compulsive disorder (OCD). One study found that 14 of 16 refractory OCD patients experienced substantial improvement in obsessive-compulsive symptoms within 3 weeks of the initiation of an SRI-risperidone combination; indeed, certain patients improved dramatically within days. A second study reported that 7 of 14 OCD patients responded with the addition of risperidone after having failed to respond to SRI therapy alone. A retrospective chart review discovered that 8 patients with OCD who had failed an SRI trial responded within a month of supplementation with risperidone.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 59

Quick Links: Obsessive-Compulsive and Related Disorders