This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Articles

Serotonin-1D Hypothesis of Obsessive-Compulsive Disorder: An Update

Article Abstract

Support for the serotonin-1D (5-HT1D) hypothesis of obsessive-compulsive disorder (OCD) andrelated conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT1D agonistsumatriptan, and case reports in which prolonged administration of 5-HT1D agonists was associatedwith a therapeutic effect, suggest that 5-HT1D may play a role in obsessive-compulsive symptoms. Geneticstudies have also found that polymorphism of the 5-HT1D gene may be preferentially transmittedto those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the5-HT1D hypothesis requires further investigation in order to disentangle the role of the 5-HT1D receptor inthis common and often severe disorder.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 65

Quick Links: Obsessive-Compulsive and Related Disorders