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Educational Activity

Pharmacotherapeutic Treatment Strategies for Antidepressant Nonresponse

Michael E. Thase, MD

Published: November 15, 2009

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders

Article Abstract

Patients who do not respond to initial antidepressant treatment are more difficult to treat and have lower odds of remission than those who fully or partially respond to initial pharmacotherapy. Potential treatment options for nonresponders include combination and switching strategies, both of which can be done within a single class of medications or across medication classes. Choosing the correct strategy and appropriate pharmaceutical option or options requires consideration of not only algorithm recommendations, but also a variety of variables including, but not limited to, the patient’s symptom and side effect profiles.

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