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Letters to the Editor

Clozapine-Benzodiazepine Interactions

Imran Faisal, J. P. Lindenmayer, Zebulon Taintor, and Robert Cancro

Published: December 15, 1997

Article Abstract

Letter to the Editor

Sir: Clozapine is an atypical antipsychotic often used in the
treatment of refractory schizophrenic patients. The manufacturer
recommends caution when combining clozapine therapy
with other CNS-active drugs, particularly benzodiazepines.
Sassim and Grohmann first reported two cases of severe collapse
with this combination. The first patient was a 51-year-old
man on diazepam 20 mg/day.

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