This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Letter to the Editor

Reply to “Intrinsic Activity of Aripiprazole Is Not 30% of Dopamine, But Only About 6% Under Ideal Antipsychotic Therapy”

Sheldon H. Preskorn, MD

Published: May 11, 2008

Article Abstract

Letter to the Editor

Sir: I appreciate the letter from Drs. Hamamura, Kodama,and Harada but must respectfully disagree with their argumentas follows:
Dr. Hamamura and colleagues suggest that the intrinsic activityof a partial receptor agonist is derived mathematicallyfrom the percentage of the target receptor occupied by differentdoses of the partial agonist versus the percentage of that receptoroccupied by its endogenous agonist under normal physiologicconditions. Instead, the intrinsic activity of a partialagonist is determined by measuring its maximal functional effecton its target receptor versus the maximal functional effectof the endogenous agonist of the same receptor. Admittedly,there should be some agreement between these 2 different conceptssince the latter is a major determinant of the former.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Volume: 69

Quick Links: