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Letter to the Editor

Reply to Letter to the Editor "Free Drug Fraction Versus Free Drug Concentration"

C. Lindsay DeVane and Bruce G. Pollock

Published: November 30, 2000

Article Abstract

Letter to the Editor

Sir: We thank Dr. Pies for his thoughtful comments andagree that the free, non-protein-bound concentration of drugs inplasma is more closely correlated with drug effect than totalconcentration. In addition, for many drugs and situations, includingdrug-drug interactions that result in displacement ofdrugs from plasma protein binding sites, the increase in freedrug concentration is transient. An exception to this generalizationwould be a drug with a high hepatic intrinsic clearancewhose plasma protein binding is nonrestrictive for eliminationand that is administered intravenously.

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Volume: 61

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