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Letter to the Editor

“Reply to Weight Gain, Sexual Dysfunction and Buropion.”

Mark Zimmerman, MD; Michael A. Posternak, MD; Naureen Attiullah, MD; Michael Friedman, MD; Robert J. Boland, MD; Scott Baymiller, MD; Stacie Lauro Berlowitz, MD; Shahzad Rahman, MD; Kirsten K. Uy, MD; Steve Singer, MD; Iwona Chelminski, PhD; and Tavi Thongy, MD

Published: October 14, 2005

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: Our recent article1 examining the factors influencingpsychiatrists’ prescription of bupropion was based on 3 propositions:(1) all antidepressant medications are generally equallyeffective2; (2) weight gain and sexual dysfunction are the 2 sideeffects that are of greatest concern to patients and have thegreatest impact on long-term compliance; and (3) bupropionis not associated with either weight gain or sexual dysfunction.Dr. Menaster questioned the accuracy of our third propositionand concluded that bupropion is associated with weight gainand sexual dysfunction. He cited 4 lines of evidence supportinghis conclusion: (1) case reports; (2) reports of weight gain in thepackage insert for bupropion extended-release (XL); (3) reportsfrom naturalistic, observational studies; and (4) the results of ameta-analysis comparing bupropion and selective serotoninreuptake inhibitors (SSRIs).’ ‹’ ‹

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Volume: 66

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