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Educational Activity

The Role of Neurobiologic Processes in Treating Depression

Michael E. Thase, MD

Published: October 15, 2010

This CME activity is expired. For more CME activities, visit
Find more articles on this and other psychiatry and CNS topics:
The Journal of Clinical Psychiatry
The Primary Care Companion for CNS Disorders


Current antidepressants work by directly affecting the neurotransmission of serotonin and norepinephrine. These neurotransmitters modulate regions of the brain associated with depression and affect the expression of genes involved in neurogenesis and neuroprotection. Treatment targets for the development of future antidepressants include medications with novel mechanisms of action, such as glutamate receptor antagonists, that may alter the stress response of gene activity and provide neuroprotection to patients with depression.


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