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The Art and Science of Switching of Antipsychotic Medications, Part 1

Peter J. Weiden, Allan H. Young, and Peter F. Buckley

Published: November 15, 2006

Article Abstract

In the presentation "Prevalence of and Factors Influencingthe Switching of Antipsychotic Medications," Weiden defines the recoveryapproach for the treatment of schizophrenia, focuses on reasons for switchingantipsychotic medications, and offers recommendations for evaluating switchstudies. In "Combining and Switching Medications in Bipolar Disorder," Youngdiscusses the similarities and differences between schizophrenia and bipolardisorder, offers recommendations for switching medications in bipolar disorder,and evaluates studies of atypical antipsychotics in the treatment of bipolardisorder. Buckley’s presentation, "Differential Pharmacology of AtypicalAntipsychotics: Clinical Implications," examines response rates in patientswith schizophrenia after switching antipsychotic medications, outlinesreceptor-binding profiles of atypical antipsychotics, highlights adverse eventsthat may occur when switching antipsychotic medications, and offersrecommendations for treating those adverse events.

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