Schizophrenia as a Manifestation of X-Linked McLeod-Neuroacanthocytosis Syndrome

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Sir: Neuroacanthocytosis syndromes represent a heterogeneous group of neurodegenerative disorders defined by the association of red blood cell (RBC) acanthocytosis and variable neurologic signs and symptoms.1 A progressive chorea syndrome comparable to the prototype Huntington’s disease represents the core clinical feature of a subgroup of neuroacanthocytosis syndromes, including the autosomal recessive choreoacanthocytosis (MIM #200150),2 the autosomal dominant Huntington’s disease-like disorder type 2 (MIM #606438),3 and the X-linked McLeod syndrome (MIM #314850).


J Clin Psychiatry 2004;65(5):722-723

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