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Letter to the Editor

Underpowered Repetitive Transcranial Magnetic Stimulation Might Not Be an Effective Antidepressant Treatment

George Kirov, PhD, MRCPsych; John Tredget, BSc; Emma Dunn, BSc; Valentina Moskvina, PHD; Roger Beer, MRCPsych; and Najeeb Khalid, MCPS, MD

Published: April 15, 2005

Article Abstract

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Sir: Koerselman et al.1 reported the results of a trial of repetitivetranscranial magnetic stimulation (rTMS) for the treatmentof depressive disorders. After 2 weeks, the improvementon the 17-item Hamilton Rating Scale for Depression (HAM-D)was not different between the active and the placebo arms of thestudy and in fact was very disappointing at 18.5% and 15.4%,respectively.

We agree with the authors that one explanation for the pooroutcome was the low setting of the stimulation parameters, especiallythe use of just 80% of motor threshold.’ ‹

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