Research Methodology

Observational studies have found associations between antidepressant drug prescription during pregnancy and autism and ADHD. But is the link actually related to genetic predisposition rather than to the antidepressant?...

An association between antidepressants during pregnancy and neurodevelopmental disorders has been found in many observational studies. But is anemia part of the culprit? Dr Andrade takes a closer look...

Do benzodiazepines pose a risk when taken during pregnancy? A recent case-control study indicated nearly doubled odds of spontaneous abortion. Dr Andrade takes a closer look at this study...

Dr Andrade considers the findings of observational studies indicating a higher risk of hip fracture in older people who take antidepressants—and whether confounding by indication can fully explain the...

Methylphenidate is related to sleep-related adverse events. This meta-analysis sought to quantify this impact of methylphenidate and determine the varieties of sleep problems associated with this drug.

Was the adverse event caused by the drug or by the condition itself? In this installment of his column, Dr Andrade points to the importance of controlling for confounding...