QTc and Metabolic Parameters

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Sir: My colleagues and I have been interested in QTc interval prolongation, torsade de pointes, and antipsychotic drugs for some time.1–9 The article by Mackin and Young10 in the November 2005 issue of the Journal has sufficient limitations both in its own right and as a model for a larger study to stimulate the following comments:

  • In the Introduction, Mackin and Young assert a need to examine “the relationship between QTc interval, antipsychotic use, and metabolic dysfunction.”10(p1387)
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J Clin Psychiatry 2006;67(5):838-839