Aripiprazole-Induced Agitation After Clozapine Discontinuation: A Case Report
J Clin Psychiatry 2009;70(1):141-143 [letter]
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Letter to the Editor
Sir: Clozapine continues to be the gold standard for patients
with treatment-refractory schizophrenia.1 However, when patients
who have responded to clozapine need to have clozapine
treatment discontinued due to a serious adverse event, such as
glucose abnormalities, clinicians are often confronted with difficult
choices regarding a suitable substitute treatment.
We present a patient who developed acute ketoacidosis
while on clozapine treatment and who developed severe agitation
and psychotic decompensation with subsequent aripiprazole