Worried Sick: Antidepressants, Stress, and Inflammation

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Antidepressants are useful for treating many disorders beyond clinical depression. In this month’s column, the concept that the main therapeutic effects of antidepressants are due to their stress-buffering properties will be discussed. Anxiety, depression, and stress are inextricably linked. Stress is operationally defined as perceived threat in combination with an inability to control the stress.1

J Clin Psychiatry 2007;68(10):1613-1614