Metabolic Side Effects of Second-Generation Antipsychotics in Children and Adolescents: A Different Story?

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In many clinical settings, secondgeneration antipsychotics are preferred over first-generation antipsychotics because they cause fewer acute1 and chronic2 neuromotor side effects. In addition, second-generation antipsychotics may have improved3,4 and broader5 efficacy and are potentially associated with somewhat lower rates of nonadherence6 compared with those of the older agents. However, since the late 1990s, the increased risk for weight gain associated with second-generation antipsychotics has become a focus of attention.​​

J Clin Psychiatry 2005;66(10):1331-1332