Introduction/Antidepressant Discontinuation Syndrome: An Update on Serotonin Reuptake Inhibitors


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When selecting an antidepressant to treat a patient suffering from depression, a physician should consider the possibility of a discontinuation reaction. Discontinuation symptoms can occur when doses are frequently missed (intermittent noncompliance), upon abrupt cessation of treatment and, less often, during dosage reduction. These symptoms have been reported with increasing frequency in the literature when the newer serotonin reuptake inhibitors (SRIs) are discontinued.

J Clin Psychiatry 1997;58(suppl 7):3–4