Remission of Panic Disorder With Mirtazapine Augmentation of Paroxetine: A Case Report

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Sir: Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant with proven efficacy in the short- and long-term treatment of panic attacks with or without agoraphobia.1 Mirtazapine is a noradrenergic and specific serotonergic antidepressant that acts by antagonizing the adrenergic α2-autoreceptors and α2-heteroreceptors, as well as by blocking serotonin 5-HT2 and 5-HT3 receptors. It enhances, therefore, the release of norepinephrine and 5-HT1A–mediated serotonergic transmission.​

Prim Care Companion J Clin Psychiatry 2007;9(5):396 [letter]