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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Semaglutide for Alcohol Use Disorder
Letter to the Editor

January 1, 2026

The authors explore potential mechanisms underlying the relationship between GLP-1 agonists and AUD as well as studies evaluating semaglutide for AUD.
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PCC
Transient Loss of Consciousness in an Adolescent with Pathological Intoxication
Case Report

January 1, 2026

This case of atypical symptoms in a 15-year-old boy underscores the need to differentiate pathological intoxication from seizures and psychiatric conditions, emphasizing alcohol abstinence.
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PCC
Machine Madness: A Case of Artificial Intelligence Psychosis
Case Report

December 30, 2025

A 41-year-old man with a history of substance-induced psychosis, developed symptoms of psychosis related to frequent occupational use of AI.
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PCC
A Case of Kratom Withdrawal
Case Report

December 25, 2025

A 29-year-old man experienced kratom withdrawal that necessitated intensive care management and resulted in subsequent cardiac arrest.
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PCC
Diagnosis and Management of Rage
Rounds in the General Hospital

December 23, 2025

This article offers a practical framework for distinguishing rage from irritability and impulsivity, identifying underlying neuropsychiatric drivers, and guiding evidence-based management across conditions including PTSD, TBI, and mood disorders.
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PCC
Clozapine-Induced Corrected QT-Interval Prolongation and Relationship With Serum Clozapine Concentration
Case Report

December 18, 2025

The author presents a case of clozapine-induced QTc prolongation and discusses its relationship with serum clozapine concentration
Figure: Journal cover summarizes articles on suicide impact, gender-affirming care, drone trauma, veteran toxins, and prenatal substance use.

Vol 27 • 2025 • Number 6

Read the Current Issue

Original Research

Impact of Patient Suicide on Mental Health Professionals

Review Article

Gender-Affirming Surgery, Gender Dysphoria, and QOL

Rounds in the General Hospital

Psychological Sequelae of Drone Attacks

Rounds in the General Hospital

Sequelae of Toxic Exposures in Veterans

Rounds in the General Hospital

Talking to Pregnant Patients About Substance Use

Case Report

Tetrabenazine-Induced Suicidality
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Cognitive Distortions in Physician Guilt
Original Research

October 21, 2025

This study examines examples of physician guilt in television and movies and identifies examples of cognitive distortions to help readers gain insight into their own potential feelings of guilt.
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PCC
Access to Primary Care in First-Episode Psychosis
Original Research

October 2, 2025

Improving engagement in primary care is critical for young adults with first-episode psychosis to establish beneficial patterns of health care use and timely access to preventative care.
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PCC
Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study
Original Research

September 11, 2025

Older adults were found to have less depression and anxiety compared to middle-aged adults; loneliness and perception of knowledge about COVID can affect the association between the presence of…
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Review Articles

PCC
Improving Community Mental Health Care
Narrative Review

October 9, 2025

This review highlights critical areas for enhancing the quality and sustainability of community mental health services.
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PCC
Precision Psychiatry for Depression Treatment
Narrative Review

September 9, 2025

Novel precision medicine tools in depression aim to identify the optimal treatment for each patient and have the potential to significantly improve depression management by guiding treatment selection for…
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PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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PCC
Climate Change and Mental Health
Review Article

July 24, 2025

This scoping review highlights the significant impact of climate change on mental health in India, particularly among individuals from lower socioeconomic backgrounds in rural areas.
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PCC
Efficacy of GLP-1 Agonists in Mental Disorders
Review Article

June 10, 2025

Current evidence underscores the potential of GLP-1 receptor agonists as a novel therapeutic approach for certain psychiatric disorders, particularly AUDs, depression, and autism-related food behaviors.
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PCC
Role of GLP-1 Receptor Agonists in AUD
Narrative Review

May 15, 2025

The authors examine the potential benefits, dosages, and mechanisms of GLP-1 receptor agonists on alcohol consumption and how they can potentially modify alcohol-seeking behavior.
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Rounds in the General Hospital

PCC
Facilitating Academic Success for Clinicians
Rounds in the General Hospital

December 16, 2025

Many clinicians, experience “imposter syndrome,” which can foster the false belief that they are unqualified for promotion.
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PCC
Using Digital Technologies to Avoid Doctor’s Orders
Rounds in the General Hospital

December 2, 2025

The availability of portable technologies and application-based services can complicate caretaking in the hospital setting, as patients can circumvent medical recommendations.
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PCC
Primary Care and Mental Health Collaboration
Rounds in the General Hospital

November 13, 2025

Since PCPs are often the first health care professionals to see patients with symptoms of a mental health disorder, they play a vital role in the identification, management, and…
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PCC
Talking to Patients About Inflammatory Bowel Diseases
Rounds in the General Hospital

November 6, 2025

Find out what triggers irritable bowel diseases and how your patients can manage their GI symptoms and utilize psychotropic agents in this comprehensive guide.
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PCC
Choosing a Pharmacologic Strategy for Psychosis
Rounds in the General Hospital

October 28, 2025

Find out which antipsychotic agent to prescribe to your patient with psychosis and learn how to balance the concepts of efficacy, tolerability, and cost.
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PCC
Impact of Hypotension on Cognitive Function
Rounds in the General Hospital

October 23, 2025

Hypotension acts synergistically to affect mental status by compounding problems with gas exchange, neurovascular dynamics, neuronal metabolism, and neurotoxicity.
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Case Reports

PCC
Balancing Pragmatism and Ethics in Psychiatry
Case Report

December 16, 2025

A psychiatrist strategically used a patient’s internalized fear of extremism to redirect behavior during a manic episode.
PCC
Bupropion for Postpartum Depression and Narcolepsy
Case Report

December 11, 2025

Bupropion was an effective pharmacologic therapy for narcolepsy with cataplexy in a 21-year-old woman with postpartum depression.
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PCC
Unstable Lithium Levels in a Bodybuilder With Bipolar Disorder
Case Report

December 11, 2025

This case highlights the importance of assessing dietary habits, supplement use, and potential anabolic steroid use, particularly in physically active patients undergoing lithium therapy.
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PCC
Is It Huntington Disease or Tardive Dyskinesia?
Case Report

December 9, 2025

A 59-year-old woman with a psychiatric history and prolonged olanzapine use has worsening abnormal movements, weight loss, and behavioral changes. She was previously diagnosed with TD.
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PCC
A Case of AVM, Hemichorea, and Depression
Case Report

December 4, 2025

A 30-year-old man presented with rapid, involuntary jerky movements on his right side, exacerbated by stress and absent during sleep, as well as low mood, hopelessness, poor concentration, anhedonia,…
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PCC
Complexities of Serotonin Syndrome
Case Report

December 4, 2025

A 58-year-old man presented to the ED due to muscle stiffness, uncontrollable limb movements, and the sensation as if his body was on fire.
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Letter to the Editor

PCC
Psychosis Screening in Genetic Disorders
Letter to the Editor

December 4, 2025

The author discusses routine monitoring for the development of psychotic symptoms among individuals with rare genetic disorders that confer risk for psychosis.
PCC
Culturally Adaptive Mental Health Care
Letter to the Editor

December 2, 2025

The author discusses the culturally adaptive work of Dr Vidya Sagar, whose mid-20th-century innovations in family-centered care laid the groundwork for India’s unique trajectory in community psychiatry.
PCC
Brain Injuries, Illness, and Treatment in Sports
Letter to the Editor

October 2, 2025

In their letter to the editor, the authors discuss the need for sports psychiatry and neurology to be viewed as a central part of the sports medicine field.
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PCC
Complicated Grief: Is There a Role for Naltrexone?
Letter to the Editor

September 23, 2025

The authors discuss prolonged grief disorder and the use of medications like naltrexone as a potential treatment.
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PCC
Knowledge of ECT for Catatonia
Letter to the Editor

September 11, 2025

The authors comment on a recent study by Kaur et al assessing what internists and neurologists know about catatonia.
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PCC
Knowledge of Catatonia: Reply to Espinoza and Kellner
Letter to the Editor

September 11, 2025

The authors reply to a letter to the editor commenting on their article.
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More Articles from The Primary Care Companion for DNS Disorders

PCC
Benzodiazepine-Induced Neurologic Dysfunction
Case Report

November 27, 2025

This case illustrates how benzodiazepine-induced neurologic dysfunction and benzodiazepine use disorder can coexist, emphasizing the importance of distinguishing between them to guide diagnosis and management.
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PCC
From Varenicline to Neuroleptic Malignant Syndrome
Case Report

November 27, 2025

This case highlights the complexity of diagnosing atypical neuroleptic malignant syndrome in high-risk individuals after sudden cessation of varenicline and cigarette smoking.
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PCC
Comorbidities Obscure Autism Diagnosis
Case Report

November 25, 2025

A 14-year-old boy with longstanding psychotic illness, posttraumatic stress from adverse social experiences, and suicidality presented for neuropsychiatric assessment.
PCC
Psychosis or Multiple System Atrophy?
Case Report

November 20, 2025

A 67-year-old woman presented with altered mental status, hallucinations, and hyperalgesia of the bilateral lower legs and was subsequently diagnosed with multiple system atrophy.
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PCC
Religious Preoccupation in Adolescence
Case Report

November 18, 2025

A 16-year-old boy developed new-onset psychosis of religious preoccupation and delusions.
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PCC
Clozapine Withdrawal–Induced Catatonia
Case Report

November 18, 2025

A patient with treatment-resistant schizophrenia developed persistent catatonia after sudden cessation of clozapine, highlighting the challenges in management and the potential role of clozapine reintroduction.
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PCC
Lumateperone-Induced Urticarial Rash in Schizophrenia
Case Report

November 13, 2025

This report describes an instance of acute generalized urticaria immediately following an initial dose of lumateperone in a 43-year-old man with schizophrenia.
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PCC
Schizophrenia With Diphenhydramine Abuse
Case Report

November 4, 2025

This report examines the effects of clozapine on diphenhydramine dependence in a 33-year-old patient with schizophrenia.
PCC
Persistent Insomnia in an Elderly Man With HIV
Case Report

October 30, 2025

An 80-year-old man with receiving antiretroviral therapy for HIV since the mid-1990s reported complete inability to sleep, leading to psychological distress and suicidal ideation.
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PCC
Cerebrotendinous Xanthomatosis: Unraveling Prominent Neuropsychiatric Symptoms and MCI
Case Report

October 30, 2025

A 51-year-old woman with an 8-month history of significant cognitive decline and behavioral changes, including forgetfulness, irritability, and anger outbursts, received an initial diagnosis of MCI.
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PCC
Neuropsychiatric Challenges of Friedreich’s Ataxia
Case Report

October 23, 2025

Management of behavioral symptoms in Friedreich’s ataxia patients requires a nuanced approach that integrates psychiatric care with traditional neurological treatment.
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PCC
Fluoxetine-Induced Extrapyramidal Symptoms
Case Report

October 21, 2025

This case highlights the underrecognized risk of extrapyramidal symptoms, particularly drug-induced parkinsonianism, associated with fluoxetine.
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Consensus Report on XT Use in Practice

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Figure: Graphic promoting Consensus Report on Xanomeline-Trospium; colorful net design shown with JCP logo in lower left.

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