Primary Care Companion for CNS Disorders Primary Care Companion for CNS Disorders

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Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Onco-Psychopharmacology: Is Mirtazapine a Catholicon?
Letter to the Editor

June 24, 2025

The author discusses the role of mirtazapine in the treatment of depression in patients with cancer.
PCC
Paroxysmal Eye Movements in Treatment-Resistant Schizophrenia
Case Report

June 19, 2025

A patient with treatment-resistant schizophrenia whose presumed oculogyric crisis was later identified as seizure-like activity, worsened with clozapine and resolved with antiepileptic treatment.
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PCC
Charles Bonnet Syndrome in a Patient With MS
Case Report

June 19, 2025

A woman with MS developed vision loss and complex visual hallucinations, raising the possibility of Charles Bonnet syndrome in the setting of a long-standing demyelinating disease.
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PCC
Time-Limited Teaching of Psychiatry to Medical Students
Rounds in the General Hospital

June 17, 2025

Educational practices such as a “flipped classroom” or “layered learning” can allow the educational experience to be better tailored to the needs of learners.
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PCC
Facing Intensive Care: A Guide for PCPs
Rounds in the General Hospital

June 17, 2025

Critically ill patients develop complex problems that involve affective, behavioral, cognitive, and motor manifestations, and failure to attend to these signs and symptoms can jeopardize the safety of both…
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PCC
Community-Based Alternatives in Behavioral Crisis Transport
Letter to the Editor

June 12, 2025

Law enforcement transport for individuals in behavioral health crises results in significant financial costs and psychological trauma, reinforcing criminalization and stigma while worsening mental health conditions.
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Vol 27 • 2025 • Number 2

Read the Current Issue

Original Research

What Internists and Neurologists Know and Think About Catatonia

Original Research

Psychological Morbidities in Hospital Staff During Nipah Virus

Systematic Review

Exercise and Fibromyalgia Pain

Rounds in the General Hospital

Managing Anxiety, Agitation, and Pain in Critically Ill Patients

Review Article

Quality Indicators in Community Mental Health Services: A Scoping Review

Case Report

Is My Patient Diverting Their Lorazepam?
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Rounds in the General Hospital Rounds from Banner Alzheimer's Institute

Original Research

PCC
Absconding During Psychiatric Inpatient Treatment
Original Research

May 13, 2025

The study highlights the importance of early risk identification, increased supervision during high-risk periods, and tailored interventions addressing clinical and organizational factors associated with absconding.
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PCC
Seasonality of Australian Medicare-Reimbursed Psychiatric Consultations
Original Research

May 8, 2025

Conventional (face-to-face) office-based psychiatric consultations show clear seasonal changes, especially among young patients, which may have a practical impact on psychiatric service planning.
, , , et al
PCC
Association of Pregnancy-Related Anxiety With Perceived Social Support: An Observational Study Among Third-Trimester Antenatal Women
Original Research

March 20, 2025

Late-pregnancy anxiety was linked to perceived social support, and specific pregnancy-related anxiety themes, such as concerns about giving birth, the child’s health, one’s own appearance, correlated with distinct perceived…
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Review Articles

PCC
Efficacy of GLP-1 Agonists in Mental Disorders
Review Article

June 10, 2025

Current evidence underscores the potential of GLP-1 receptor agonists as a novel therapeutic approach for certain psychiatric disorders, particularly AUDs, depression, and autism-related food behaviors.
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PCC
Role of GLP-1 Receptor Agonists in AUD
Narrative Review

May 15, 2025

The authors examine the potential benefits, dosages, and mechanisms of GLP-1 receptor agonists on alcohol consumption and how they can potentially modify alcohol-seeking behavior.
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PCC
Dextromethorphan-Quinidine for Agitation in Dementia
Narrative Review

November 14, 2024

The authors provide an updated summary of the literature on dextromethorphan-quinidine for the treatment of agitation in patients with dementia.
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PCC
Improving Collaboration Between Neuropsychology and Primary Care
Narrative Review

October 31, 2024

Collaboration between neuropsychologists and physicians significantly improves patient care by enhancing diagnostic precision and treatment planning. Read on to find out more.
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PCC
Understanding the Child and Adolescent Mental Health Crisis
Narrative Review

October 24, 2024

The authors delve into current mental health challenges facing children and youth, examining perspectives from both pre-pandemic and pandemic periods.
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PCC
Management of Sleep Disturbances in Veterans Following Mild TBI
Narrative Review

September 12, 2024

The authors developed an evidence- and consensus-based clinical recommendation regarding primary care management of insufficient and disturbed sleep associated with concussion/mild traumatic brain injury in service members and veterans.
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Rounds in the General Hospital

PCC
Multimodal Approaches to Pain Management
Rounds in the General Hospital

June 3, 2025

Although the primary objective of managing acute pain is to provide effective pain relief, it is also important to minimize medication side effects, improve patient function, and reduce the…
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PCC
Managing Psychotic Illnesses in Primary Care
Rounds in the General Hospital

May 22, 2025

Symptoms of psychosis, while often nonspecific, may involve complaints of physical ailments and lead to primary care visits.
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PCC
Sequelae of Adverse Childhood Experiences
Rounds in the General Hospital

May 6, 2025

Long-term complications of ACEs involve psychiatric and medical conditions, such as mood and substance use disorders, chronic heart and lung diseases, obesity, diabetes, cancer, and PTSD.
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PCC
Wishing That Your Patient Would Die: Reasons and Reactions
Rounds in the General Hospital

February 25, 2025

The authors explore the complexity, intensity, and critical decision-making faced by health care staff while caring for chronically and critically ill patients, especially in the context of medical futility.
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PCC
Psychosis-Related PTSD
Rounds in the General Hospital

February 6, 2025

Frightening psychotic experiences might serve as traumatic events and precipitate development of PTSD, and the first step to successful management is ensuring a proper assessment.
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PCC
Prolonged Grief: Etiology and Management
Rounds in the General Hospital

February 4, 2025

Prolonged grief disorder has several features that overlap with depression and PTSD but is a distinct entity for which a well-validated, targeted treatment is available.
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Case Reports

PCC
Recognizing Cotard Syndrome in the ED
Case Report

June 12, 2025

Cotard syndrome can increase a patient’s risk for self-harm, self-starvation, and suicide, so it is imperative that early recognition occurs, especially in the ED.
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PCC
β-blocker/Colchicine Coingestion With Cocaine Intoxication
Case Report

June 5, 2025

The authors describe a case in which cocaine-induced cardiac toxicity initially masked β-blocker (carvedilol) toxicity and suggest improvements in management for similar cases.
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PCC
Excited Catatonia in Opioid and Benzodiazepine Withdrawal
Case Report

June 5, 2025

A 37-year-old man developed excited catatonia in the setting of concurrent opioid and benzodiazepine withdrawal, requiring high dosages of benzodiazepines to resolve.
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PCC
PRES With Obstructive Hydrocephalus
Case Report

May 29, 2025

A man with history of severe hypertension, hyperthyroidism, and cocaine and methamphetamine use presented with severe headache, nausea, dizziness, and bright spots in his left eye.
, , , et al
PCC
Antibiotic-Related Psychotic Episodes in Adolescents
Case Report

May 27, 2025

The authors present a case of first-episode psychosis in a 17-year-old male following amoxicillin administration.
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PCC
Prolonged Delirium After ECT
Case Report

May 20, 2025

The authors present a case of prolonged ECT-associated delirium in a 65-year-old woman, offering insights into the proposed pathophysiology.
, , , et al

Letter to the Editor

PCC
Revisiting Ayahuasca: Vine of the Soul of the Amazon
Letter to the Editor

March 18, 2025

The authors comment on a case report previously published in the PCC describing psychosis and ayahuasca use and discuss the need for further research given its increased usage worldwide.
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PCC
Cannabis Withdrawal Psychosis
Letter to the Editor

March 13, 2025

Dr Gorelick comments on a case report recently published in the PCC.
PCC
Cannabis Withdrawal Psychosis: Reply to Gorelick
Letter to the Editor

March 13, 2025

The authors reply to a letter to the editor commenting on their case report.
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PCC
Parenting Young Adults With ADHD
Letter to the Editor

February 13, 2025

The authors explore the role of parental involvement in supporting young adults with ADHD.
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PCC
Letter to the Editor

December 10, 2024

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PCC
Is Bariatric Surgery an Antidepressant?
Letter to the Editor

October 29, 2024

The effect of bariatric surgery on mood disorders is uncertain. Read on to find out more.

More Articles from The Primary Care Companion for DNS Disorders

PCC
Psychiatric Adverse Effects of Hydroxychloroquine
Systematic Review

May 29, 2025

Hydroxychloroquine use is associated with various neuropsychiatric adverse effects, cognitive impairments, and behavioral changes.
, , , et al
PCC
Is It Munchausen or Is It Dementia?
Case Report

May 15, 2025

This case elucidates the diagnostic challenges associated with differentiating frontotemporal dementia from aggravating personality disorder or behavioral variant frontotemporal dementia.
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PCC
Risperidone Long-Acting Injection Reduced Emergency Visits in a Patient With Comorbid Autism Spectrum and Borderline Personality Disorders
Case Report

May 1, 2025

This case demonstrates that LAI risperidone may support emotional and interpersonal improvements in a patient with both borderline personality disorder and autism spectrum disorder.
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PCC
Pirfenidone-Induced Fear of Forgetting
Case Report

May 1, 2025

The authors report an unusual association of pirfenidone and athazagoraphobia, leading to its discontinuation in idiopathic pulmonary fibrosis.
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PCC
Delusions of Parasitosis With Methylphenidate
Case Report

April 29, 2025

A 70-year-old woman developed delusions of parasitosis extended-release methylphenidate after taking it for more than 6 years.
PCC
Neuropsychiatric Presentation of Vitamin B12 Deficiency
Case Report

April 24, 2025

This case describes a 59-year-old woman with borderline B12 deficiency presenting with only neuropsychiatric symptoms
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PCC
Shock Anxiety After Electrical Storm Treated With CBT
Case Report

April 24, 2025

A patient with arrhythmogenic right ventricular dysplasia/cardiomyopathy, who had recently experienced electrical storm from her implantable cardioverter-defibrillator, developed shock anxiety with phobic avoidance.
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PCC
Secondary Delusional Infestation in a Male with a History of Polysubstance Use
Case Report

April 22, 2025

A 20-year-old man with a history of polysubstance use presented to the ED with a severe pruritic lesion in the left scapular region. Over the past 22 days, he…
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PCC
Oxcarbazepine/Aripiprazole Interaction and Bipolar Relapse
Case Report

April 10, 2025

This case highlights the interaction between aripiprazole and oxcarbazepine, resulting in subtherapeutic levels of aripiprazole and recurrence of manic symptoms in a patient with bipolar I disorder.
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PCC
First-Episode Psychosis and Cushing Syndrome
Case Report

March 25, 2025

A 72-year-old man with no prior psychiatric history was diagnosed with new-onset psychosis in the setting of hypercortisolism.
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PCC
Thought Broadcasting and Cultural Beliefs
Case Report

March 18, 2025

A 42-year-old woman attributed her thought broadcasting to the possession of a Ruhani, a type of jinn believed to have the power to influence human thoughts and behaviors.
PCC
Biofeedback for Functional Vomiting Management
Case Report

March 11, 2025

The authors describe 2 patients who responded to biofeedback-based behavioral interventions for functional vomiting.
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