Dr. Berigan Replies

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Sir: Dr. Johnson’s interest in our reported case of bupropion-associated withdrawal symptoms is greatly appreciated. As was pointed out in the case report, the exact mechanism responsible for the somatic and psychological symptoms is not known. It is believed that many neurotransmitters may be involved, including the noradrenergic and dopaminergic sites, which appear to be where bupropion exerts its effects.1

Prim Care Companion J Clin Psychiatry 1999;1(5):165