Diary From the Front Line: Irritable Bowel...or Simply Irritable?

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TG is a 42-year-old fellow whom I have been treating with venlafaxine XR for his first bout with depression. He had been significantly symptomatic for about a year before treatment and responded to a 150-mg dose and counseling. Well, it has been about a year, and spring has been beautiful, so we have decided to wean him from his medication. In spite of a slow taper, twice he developed significant dysphoria that persisted for several days and completely resolved by resuming a 37.5-mg dose.​

Prim Care Companion J Clin Psychiatry 2000;2(2):58-59