Discontinuation of Therapy With Bupropion SR

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Sir: In the April 1999 issue of the Companion, Drs. Berigan and Harazin1 report a case of possible bupropion-associated withdrawal symptoms in a patient treated for smoking cessation. The authors describe the emergence of a number of symptoms following abrupt discontinuation of bupropion sustained-release (SR). The occurrence of withdrawal symptoms or a discontinuation syndrome with bupropion has been extensively evaluated in smoking cessation and depression development programs involving over 10,000 patients. In clinical trials (references 2 and 3 and Glaxo Wellcome Inc., data on file), patients were monitored for the emergence of posttreatment adverse events 1 week after abrupt discontinuation of therapy.​

Prim Care Companion J Clin Psychiatry 1999;1(5):165-165