Effect of Citalopram on Blood Desipramine Levels

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Sir: We report a case of treatment-resistant major depression and panic disorder with agoraphobia treated with desipramine and augmented with citalopram without altered blood levels of desipramine.

Case report: Ms. A is a 54-year-old married white woman with DSM-IV major depression and panic disorder with agoraphobia. She has a history of panic attacks since age 20 and had presented 1 year earlier for psychiatric consultation owing to increasing symptoms of depression, which included low mood, poor concentration, suicidal thoughts, and despair. She had difficulty going to large shops and gatherings and also had difficulty leaving home.​

Prim Care Companion J Clin Psychiatry 2000;2(1):28-28