Modafinil Treatment of Excessive Daytime Sedation and Fatigue Associated With Topiramate

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Sir: Over the past several years, the amount of research in the use of newer anticonvulsants in the treatment of bipolar disorder has increased.1 Topiramate is one of those newer anticonvulsants, described in 1998 by Marcotte,2 in the treatment of bipolar disorder. Vieta et al.3 indicate that adjunctive topiramate may be useful in the long-term treatment of bipolar spectrum disorders in the most difficult-to-treat patients. Most adverse effects of topiramate are related to the central nervous system and include sedation and fatigue.4​

Prim Care Companion J Clin Psychiatry 2002;4(6):249-250