Possible New Causes For False-Positive Diagnosis of Pheochromocytoma: Lamotrigine, Aripiprazole, or the Combination

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Sir: Pheochromocytomas are rare neuroendocrine tumors diagnosed by elevated plasma and/or urine catecholamines or their metabolites.1,2 Medications reported to cause false-positive serum or urine studies include acetaminophen, phenoxybenzamine, amitriptyline, labetolol, haloperidol, levodopa, tamsulosin, venlafaxine, hydrochlorothiazide, and buspirone.2,3 We report a case in which lamotrigine, aripiprazole, or both caused symptoms and biochemical evidence suggesting pheochromocytoma that resolved when the drugs were discontinued.​

Prim Care Companion J Clin Psychiatry 2007;9(2):154