Thyroid Augmentation of Mirtazapine: A Case Report

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Sir: Depression is a common but debilitating illness in the United States with a prevalence rate ranging from 4.8% to 9.2% in primary care practice.1 Fortunately, there are many antidepressant medications to treat patients with depression. However, up to 46% of patients treated with antidepressants do not adequately respond to treatment.2 A smaller number 5% to 10% will continue to experience depression despite numerous therapeutic interventions.3 Clinicians are then left to treat these patients who do not experience a full response using a number of treatment options.

Prim Care Companion J Clin Psychiatry 2000;2(1):27-28