Original Research
Original Research
Lack of Generalizability of PTSD Treatment Trials: The Recent Brexpiprazole-Sertraline Trials as an Example
November 26, 2025
In an outpatient psychiatry sample, nearly 95% of patients who want treatment for PTSD would not have qualified for the trials of brexpiprazole-sertraline for PTSD.
Original Research
Triple Network Model–Based Functional Dysconnectivity in Young People With Major Affective Disorders With or Without Suicidal Ideation
November 19, 2025
In young people with major affective disorders, suicidality is associated with extensive functional dysconnectivity in the triple networks (default mode network, salience network, and frontoparietal network).
Original Research
Effect of Adjuvant Metformin on Adherence to and Persistence of Treatment With SGAs in Nondiabetic Patients
November 17, 2025
Use of metformin with second-generation antipsychotics (SGAs) was associated with improved adherence and persistence to SGAs at both 180- and 365-day follow-up in adults with Medicaid and commercial insurance.
Original Research
Targeting Intolerance of Uncertainty during Pregnancy: A Randomized Controlled Trial to Prevent Postpartum Anxiety Disorders
November 5, 2025
A 6-week CBT protocol targeting intolerance of uncertainty significantly reduced the risk of postpartum anxiety disorder onset versus care as usual, and patient satisfaction with treatment was high.
Original Research
Neurocognition and Impulsivity in Veterans with Bipolar Spectrum Disorders: Suicide Attempters Versus Nonattempters
October 29, 2025
Poorer working memory is associated with suicide attempt independent of depression, while verbal learning impairments associated with suicide attempt may be influenced by depression.
Original Research
Brief Video Intervention to Increase Treatment-Seeking Intentions in Young Adults
October 27, 2025
This brief video intervention was associated with greater increases in treatment-seeking intentions in people with self-reported psychiatric symptoms who were not previously engaged in the mental healthcare system and...
Original Research
Autoimmune Diseases, Treatments, and Dementia Risk: A Population-Based Case-Control Study from Taiwan
October 15, 2025
Thirteen autoimmune diseases were linked with an elevated dementia risk, particularly Behçet's disease, multiple sclerosis, and lupus. Associations with vascular dementia were stronger than with Alzheimer's disease.
Original Research
Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
October 13, 2025
This pilot trial suggests that brexpiprazole might be beneficial in reducing substance craving and use and improve quality of life in this difficult-to-treat patient population.
Original Research
Effects of Interpersonal and Social Rhythm Therapy on Suicidal Ideation in Adults with Bipolar II Depression
September 29, 2025
There was no significant difference in suicidal ideation in those receiving IPSRT plus placebo vs IPSRT plus quetiapine. IPSRT has the potential to mitigate suicidal ideation in patients with...
Original Research
Aripiprazole or Bupropion Augmentation vs Switching to Bupropion in Treatment Resistant Depression
September 22, 2025
In this model, augmentation with bupropion better balanced efficacy and tolerability in TRD in adults under 85 than did switching to bupropion or augmentation with aripiprazole. Augmentation with aripiprazole...
Original Research
Comparative Effects of Repeated Ketamine Infusion vs Intranasal Esketamine in Patients with Treatment Resistant Depression: A Retrospective Chart Review
September 22, 2025
In this naturalistic sample of patients with similarly severe treatment resistant depression treated over a 4- to 5-week induction period, intravenous racemic ketamine was associated with more rapid response...
Original Research
Relationships between Prenatal Body Composition and Mental Health Are Moderated by Physical Activity and Diet
September 15, 2025
Higher body fat mass during pregnancy is associated with more depression and anxiety symptoms. However, physical activity and adherence to high-quality diets can lessen these effects.
