Daniel Kapustin, MD
University of Toronto, Toronto, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Original Research
Neuropsychiatric Symptom Clusters and Brain Structure in Alzheimer’s Disease
March 16, 2026
Neuropsychiatric symptoms in Alzheimer’s disease separate into hyperactivity, psychosis, neurovegetative, and affective clusters, supporting a cluster-based paradigm linking behavioral symptoms with brain structure and functional decline.