Frank J. Vocci, PhD

Friends Research Institute, Baltimore, Maryland

  • 3Articles
  • 12.1KReads1
  • 2024–2025Active
  • 22Collaborators
  • 24Citations2

About

Frank J. Vocci, PhD, is affiliated with Friends Research Institute in Baltimore, Maryland. Vocci has published research focused on the use of esmethadone as a treatment for major depressive disorder (MDD), including studies on its classification as an investigational NMDAR antagonist, its long-term safety and efficacy, and its effectiveness in patients with inadequate response to standard antidepressants. The work spans clinical trials and safety evaluations, contributing to the understanding of novel rapid antidepressant therapies.

Publications

JCP
Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides
Letter to the Editor

Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides

September 8, 2025

The authors reply to Ferré and Michaelides’ letter commenting on their recent study of long-term esmethadone treatment in MDD.
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JCP
Long-Term Safety and Efficacy of Esmethadone in MDD
Original Research

Long-Term Safety and Efficacy of Esmethadone in MDD

February 17, 2025

A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
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JCP
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
Original Research

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
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1 Read counts for articles published before 2020 may include some non-human traffic.

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