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Frank L. Sapienza, MS
JCP
Original Research
Long-Term Safety and Efficacy of Esmethadone in MDD
February 17, 2025
A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
Maurizio Fava
,
Luca Pani
,
Sara De Martin
, et al
JCP
Original Research
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
June 17, 2024
Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
Maurizio Fava
,
Luca Pani
,
Sara De Martin
, et al
