Joseph B. Orange, PhD
Canadian Centre for Activity and Aging, University of Western Ontario, London, Ontario, Canada; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada
Original Research
Neuropsychiatric Symptom Clusters and Brain Structure in Alzheimer’s Disease
March 16, 2026
Neuropsychiatric symptoms in Alzheimer’s disease separate into hyperactivity, psychosis, neurovegetative, and affective clusters, supporting a cluster-based paradigm linking behavioral symptoms with brain structure and functional decline.
