Luca Pani, MD

Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, Florida; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

JCP
Esmethadone (REL-1017) in Patients with Major Depressive Disorder and Antidepressant Tachyphylaxis
Original Research

October 6, 2025

Esmethadone may be a potentially safe and effective adjunctive treatment for patients with MDD and antidepressant tachyphylaxis.
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JCP
Long-Term Safety and Efficacy of Esmethadone in MDD
Original Research

February 17, 2025

A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
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JCP
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
Original Research

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
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JCP
Effect of Time From Onset of MDD on Response to Esmethadone
Original Research

May 13, 2024

Esmethadone 25 and 50 mg were more effective in reducing depression scale scores in patients who had a shorter time since their first major depressive episode.
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PCC
REL-1017 Effects on Cognition in MDD
Original Research

February 14, 2023

REL-1017 improved subjective measures of cognitive impairment, in addition to improving total MADRS and SDQ scores.
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JCP
Article

December 28, 2016

Depression is very common in the elderly, a population often prescribed several treatments simultaneously. Find out how often antidepressants are prescribed and adhered to in this population and how...
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