Madhukar H. Trivedi, MD
University of Texas Southwestern Medical Center, Dallas, Texas
Original Research
Effect of Aripiprazole or rTMS Augmentation Versus Switching to Venlafaxine on Quality of Life
August 11, 2025
Augmentation with aripiprazole, but not rTMS, improved quality of life significantly versus venlafaxine XR/duloxetine switch in patients with treatment-resistant depression.
Original Research
Early Change in Depressive Symptom Severity with Naltrexone-Bupropion Combination and Its Association with Reduction in Methamphetamine Use: ADAPT-2 Trial
July 30, 2025
Improvement in depression accounted for approximately 25% of the treatment effect of naltrexone-bupropion on methamphetamine treatment response.
Original Research
A Comparison of 3 Scales for Measuring Adolescent Depression
December 18, 2023
Three patient-reported outcomes—Patient Health Questionnaire for Adolescents, Quick Inventory of Depressive Symptomatology–Self-Report, and Very Quick Inventory of Depressive Symptomatology–Self-Report—can assess depressive symptom severity and change over time. Scores on...
Original Research
Effect of Benzodiazepines on Antidepressant Effects of Ketamine
November 14, 2022
Findings of studies examining the impact of benzodiazepines on antidepressant effects of ketamine are contradictory. This study assessed whether concomitant oral benzodiazepines differentially affected treatment response to ketamine versus...
Insights
Association of Pain With Irritability and Depression: Findings from EMBARC, STRIDE, and the VitalSign6 Project
April 13, 2021
In this video, Dr Trivedi discusses 3 studies that used a brief self-report measure of pain (the P-FIBS) and investigated the relationships among pain, depression, and irritability.
Insights
Talking With Patients Who Have Major Depressive Disorder About the Benefits and Risks Associated With Atypical Antipsychotics
April 6, 2021
Learn how to talk with patients who have major depressive disorder about antipsychotic treatment in a way that is clear and balanced and addresses patients’ potential concerns about taking...
