Paggard Champasa, PhD

DAJE Lifesciences, LLC, Somerville, Massachusetts

  • 3Articles
  • 12.9KReads1
  • 2024–2025Active
  • 25Collaborators
  • 27Citations2

About

Paggard Champasa, PhD, is affiliated with DAJE Lifesciences, LLC in Somerville, Massachusetts. Champasa has published research focusing on the use of esmethadone (REL-1017) in patients with major depressive disorder (MDD), including studies on its efficacy, safety, and effects in cases of antidepressant tachyphylaxis and inadequate response to standard treatments. The work spans phase 3 randomized controlled trials and a 12-month open-label study. Frequent collaborators include Andrea Mattarei, Clotilde Guidetti, Cornelia Kröger, Franco Folli, and Luca Pani.

Publications

JCP
Esmethadone (REL-1017) in Patients with Major Depressive Disorder and Antidepressant Tachyphylaxis
Original Research

Esmethadone (REL-1017) in Patients with Major Depressive Disorder and Antidepressant Tachyphylaxis

October 6, 2025

Esmethadone may be a potentially safe and effective adjunctive treatment for patients with MDD and antidepressant tachyphylaxis.
, , , et al
JCP
Long-Term Safety and Efficacy of Esmethadone in MDD
Original Research

Long-Term Safety and Efficacy of Esmethadone in MDD

February 17, 2025

A durable improvement in MDD symptoms for up to 1 year was observed with esmethadone with high rates of response and remission.
, , , et al
JCP
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
Original Research

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
, , , et al

1 Read counts for articles published before 2020 may include some non-human traffic.

2 Citation counts provided by Crossref.

Physicians Postgraduate Press, Inc. (PPP) makes no warranties about the accuracy or completeness of any information published in The Journal of Clinical Psychiatry or other PPP materials, and disclaims liability for any use or non-use of that information. Clinicians should not rely solely on these materials and should exercise their own professional judgment when making patient care decisions on an individualized basis.

Insightful. Evidence-based. Human-centered.

Listen Now
The Journal of Clinical Psychiatry podcast cover with Benjamin Brody, MD

Subscribe to read
more articles

Subscribe