Paolo L. Manfredi, MD
MGGM Therapeutics, Kerhonkson, New York
Letter to the Editor
Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides
September 8, 2025
The authors reply to Ferré and Michaelides’ letter commenting on their recent study of long-term esmethadone treatment in MDD.