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It Takes Guts to Be Mentally Ill, Part 1: A Brief Overview of the Human Gut Microbiota
September 8, 2025
Dr. Henry Nasrallah introduces the human gut microbiota and its role in brain health, highlighting how early life, diet, antibiotics, and lifestyle impact microbial balance — and how gut...
Insights
It Takes Guts to Be Mentally Ill, Part 2: The Relationship Between the Gut Microbiota and Psychosis
September 8, 2025
Dr. Henry Nasrallah examines how gut microbiota imbalances—aka "leaky gut"—are linked to psychiatric conditions like depression, anxiety, and psychosis, and explores how diet, probiotics, and microbiome therapies may improve...
Insights
Update on Current & Emerging Treatments for Negative Symptoms in Schizophrenia
February 21, 2025
In this video, Dr. Kantrowitz provides an in-depth update on current and emerging treatments for the negative symptoms of schizophrenia. He discusses symptom classifications, key clinical trials, and potential...
Insights
The Near-Term Future of Muscarinic Agonists and Modulators for Schizophrenia: M1 and/or M4
February 21, 2025
In this video, Dr. Kantrowitz explores the potential of muscarinic acetylcholine receptor (mACHR) agonists and modulators for schizophrenia treatment, with a focus on M1 and M4 receptors. He reviews...
Recent JCP Articles on Insights
Insights
Optimizing Recovery: Comprehensive Care Pathways for Depression
October 7, 2024
In this video, Dr. Jay Fournier discusses the challenges of outpatient depression care, including access issues, placebo response, and maintaining sustained remission. He outlines a stepped approach to treatment...
Insights
Surgical Interventions in Treatment Resistant Depression
October 7, 2024
Patricio Riva Posse, MD, discusses advanced surgical interventions for treatment-resistant depression, including vagus nerve and deep brain stimulation. This presentation explores relapse rates, alternative therapies, and the potential for...
Recent PCC Articles on Insights
Featured Insights Research
Consensus Statement
Next-Step Treatment Options for Treatment-Resistant Depression
January 21, 2026
Strong consensus emerged for augmentation with second-generation antipsychotics, TMS, and ketamine/esketamine in the base vignette. Preferences shifted to include non-augmentative antidepressants and ECT based on patient characteristics.
Insights
What are the Efficacy and Safety of Muscarinic Receptor Modulators in Patients With Schizophrenia?
November 19, 2024
In this video, Dr. Correll examines the therapeutic potential of the muscarinic receptor system in schizophrenia treatment. He discusses how targeting muscarinic receptors may address cognitive and functional impairments,...
Insights
What is the Place of Muscarinic Receptor Modulators in the Clinical Care of Patients With Schizophrenia?
November 19, 2024
This video features Dr. Christoph Correll discussing the clinical application of muscarinic receptor modulators in schizophrenia treatment. He explores their unique mechanism of action, compares them to traditional antipsychotics,...
Insights
Prevalence and Determinants of Everyday Disability in Schizophrenia
October 31, 2024
In this video, Philip D. Harvey, PhD discusses the multifaceted nature of disability in schizophrenia, highlighting the impact of cognitive impairments, functional capacity, and negative symptoms on everyday outcomes...
