Insights
Recently published articles about Insights
Insights
It Takes Guts to Be Mentally Ill, Part 1: A Brief Overview of the Human Gut Microbiota
September 8, 2025
Dr. Henry Nasrallah introduces the human gut microbiota and its role in brain health, highlighting how early life, diet, antibiotics, and lifestyle impact microbial balance — and how gut...
Insights
It Takes Guts to Be Mentally Ill, Part 2: The Relationship Between the Gut Microbiota and Psychosis
September 8, 2025
Dr. Henry Nasrallah examines how gut microbiota imbalances—aka "leaky gut"—are linked to psychiatric conditions like depression, anxiety, and psychosis, and explores how diet, probiotics, and microbiome therapies may improve...
Insights
Update on Current & Emerging Treatments for Negative Symptoms in Schizophrenia
February 21, 2025
In this video, Dr. Kantrowitz provides an in-depth update on current and emerging treatments for the negative symptoms of schizophrenia. He discusses symptom classifications, key clinical trials, and potential...
Insights
The Near-Term Future of Muscarinic Agonists and Modulators for Schizophrenia: M1 and/or M4
February 21, 2025
In this video, Dr. Kantrowitz explores the potential of muscarinic acetylcholine receptor (mACHR) agonists and modulators for schizophrenia treatment, with a focus on M1 and M4 receptors. He reviews...
Recent JCP Articles on Insights
Original Research
Brexpiprazole for the Treatment of Co-Occurring Schizophrenia and Substance Use Disorder
October 13, 2025
This pilot trial suggests that brexpiprazole might be beneficial in reducing substance craving and use and improve quality of life in this difficult-to-treat patient population.
Brief Report
Treatment with (Es)ketamine in Catatonia: A Systematic Review of Case Reports
October 13, 2025
Recent evidence suggests that NMDA receptor antagonists, such as ketamine, may offer benefit in catatonia. This systematic review was conducted to evaluate the efficacy and safety of ketamine and...
