Vol 81, No 3 | The Journal of Clinical Psychiatry

Editorial

Addressing the Experience of Children and Adolescents During the COVID-19 Pandemic

J Clin Psychiatry 2020;81(3):20ed13394

Karen Dineen Wagner, MD, PhD

Consensus Statement

Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie

J Clin Psychiatry 2020;81(3):19cs13169

Georgios Schoretsanitis, MD, PhD^a ; John M. Kane, MD^a,b ; Christoph U. Correll, MD^a,b,c ; Stephen R. Marder, MD^d ; Leslie Citrome, MD, MPH^e ; John W. Newcomer, MD^f ; Delbert G. Robinson, MD^a,b ; Donald C. Goff, MD^g ; Deanna L. Kelly, PhD^h ; Oliver Freudenreich, MDⁱ ; Daria Piacentino, MD, PhD^j ; Michael Paulzen, MD^k ; Andreas Conca, MD^l ; Gerald Zernig, MD^m ; Ekkehard Haen, MD, PhDⁿ ; Pierre Baumann, PhD^o ; Christoph Hiemke, PhD^p ; Gerhard Gründer, MD^q

Meta-Analysis

Effect of Continuing and Discontinuing Medications on Quality of Life After Symptomatic Remission in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

J Clin Psychiatry 2020;81(3):19r13015

Noa Tsujii, MD, PhD^a ; Takashi Okada, MD, PhD^b ; Masahide Usami, MD, PhD^c ; Hidenori Kuwabara, PhD^d ; Junichi Fujita, MD, PhD^e ; Hideki Negoro, MD, PhD^f ; Michiyo Kawamura, BHHSc^g ; Junzo Iida, MD, PhD^h ; Takuya Saito, MD, PhDⁱ

Meta-Analysis

Efficacy, Effect on Mood Symptoms, and Safety of Deep Brain Stimulation in Refractory Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

J Clin Psychiatry 2020;81(3):19r12821

Filipe Peste Martinho, MD^a ; Gonçalo Silva Duarte, MD^b,c ; Frederico Simões do Couto, MD, PhD^d

Meta-Analysis

Interventions and Transition in Youth at Risk of Psychosis: A Systematic Review and Meta-Analyses

J Clin Psychiatry 2020;81(3):17r12053

Daniel J. Devoe, MSc^a ; Megan S. Farris, MSc^a ; Parker Townes, BSc^a ; Jean Addington, PhD^a

Review Article

Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review

J Clin Psychiatry 2020;81(3):19r12965

Anna-Sophie Rommel, PhD^a,* ; Veerle Bergink, PhD, MD^a,b ; Xiaoqin Liu, PhD^c ; Trine Munk-Olsen, PhD^c,d,e ; Nina Maren Molenaar, PhD, MD^a

Original Research

Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care: Phase 3, Randomized, Double-Blind, Active-Control ALPINE Study

J Clin Psychiatry 2020;81(3):19m13207

Peter J. Weiden, MD^a ; Amy Claxton, PhD^a ; Jelena Kunovac, MD^b ; David P. Walling, PhD^c ; Yangchun Du, PhD^a ; Baiyun Yao, PhD^a ; Sergey Yagoda, MD, PhD^a ; Ilda Bidollari, MD, MBA^a ; Elizabeth Keane, BA^a ; Ethan Cash, BS^a

Original Research

Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent: Double-Blind, Randomized Study (ASPIRE I)

J Clin Psychiatry 2020;81(3):19m13191

Dong-Jing Fu, MD, PhD^a ; Dawn F. Ionescu, MD^b ; Xiang Li, PhD^c ; Rosanne Lane, MAS^c ; Pilar Lim, PhD^c ; Gerard Sanacora, MD, PhD^d ; David Hough, MD^a ; Husseini Manji, MD^a ; Wayne C. Drevets, MD^b ; Carla M. Canuso, MD^a

Original Research

Contributing Factors to Heterogeneity in the Timing of the Onset of Nonfatal Suicidal Behavior: Results From a Nationally Representative Study

J Clin Psychiatry 2020;81(3):19m13017

Nicolas Hoertel, MD, MPH, PhD^a,b,c ; Julien Sabatier, MD^a ; Carlos Blanco, MD, PhD^d ; Mark Olfson, MD, MPH^e ; Jean-Pierre Schuster, MD^f ; Guillaume Airagnes, MD, PhD^a,b,g,h ; Hugo Peyre, MD, PhD^i,j ; Frédéric Limosin, MD, PhD^a,b,c

Original Research

Suicide Attempts Among Pregnant and Postpartum Women in Japan: A Nationwide Retrospective Cohort Study

J Clin Psychiatry 2020;81(3):19m12993

Daisuke Shigemi, MD^a ; Miho Ishimaru, MPH^a ; Hiroki Matsui, MPH^a ; Kiyohide Fushimi, PhD^b ; Hideo Yasunaga, PhD^a

Original Research

Efficacy and Safety of Guanfacine Extended-Release in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Randomized, Double-Blind, Placebo-Controlled Study

J Clin Psychiatry 2020;81(3):19m12979

Akira Iwanami, MD, PhD^a ; Kazuhiko Saito, MD, PhD^b ; Masakazu Fujiwara, PhD^c ; Daiki Okutsu, MS^d ; Hironobu Ichikawa, MD, PhD^e

Original Research

Machine Learning Algorithms in Suicide Prevention: Clinician Interpretations as Barriers to Implementation

J Clin Psychiatry 2020;81(3):19m12970

Lily A. Brown, PhD^a ; Kathy Benhamou, BA^a,b ; Alexis M. May, PhD^c ; Wenting Mu, PhD^a ; Richard Berk, PhD^d

Original Research

Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2)

J Clin Psychiatry 2020;81(3):19m12891

Ewa Wajs, MD, PhD^a ; Leah Aluisio, MS^b ; Richard Holder, MBA^c ; Ella J. Daly, MD^d ; Rosanne Lane, MAS^d ; Pilar Lim, PhD^e ; Joyce E. George, MS^e ; Randall L. Morrison, PhD^e ; Gerard Sanacora, MD, PhD^f ; Allan H. Young, MD, PhD^g,h ; Siegfried Kasper, MDⁱ ; Ahmad Hatim Sulaiman, PhD^j ; Cheng-Ta Li, MD, PhD^k ; Jong-Woo Paik, MD, PhD^l ; Husseini Manji, MD^d ; David Hough, MD^e ; Jennifer Grunfeld, MBBS^m ; Hong Jin Jeon, MD, PhDⁿ ; Samuel T. Wilkinson, MD^f ; Wayne C. Drevets, MD^b,‡ ; Jaskaran B. Singh, MD^b,‡

Original Research

Evaluation of Cardiometabolic Risk in a Large Psychiatric Cohort and Comparison With a Population-Based Sample in Switzerland

J Clin Psychiatry 2020;81(3):19m12796

Céline Dubath, PharmD ; Aurélie Delacrétaz, PhD ; Ana×¯s Glatard, PhD ; Peter Vollenweider, MD ; Martin Preisig, MD, MPH ; Hél×¨ne Richard-Lepouriel, MD ; Roland Hasler, PhD ; Franziska Gamma, MD, MSc ; Alessandra Solida, MD ; Jacques Thonney, MD ; Sylfa Fassassi, MD ; Armin von Gunten, MPhil, MD ; Philippe Conus, MD ; Chin B. Eap, PhD

Original Research

Metabolic Effects of 7 Antipsychotics on Patients With Schizophrenia: A Short-Term, Randomized, Open-Label, Multicenter, Pharmacologic Trial

J Clin Psychiatry 2020;81(3):19m12785

Yamin Zhang, PhD^a,b ; Qiang Wang, MD^a,b ; Gavin P. Reynolds, PhD^c ; Weihua Yue, MD, PhD^d,e ; Wei Deng, MD^a,b ; Hao Yan, MD^d,e ; Liwen Tan, MD^f ; Chuanyue Wang, MD, PhD^g ; Guigang Yang, MD^h ; Tianlan Lu, MD^d,e ; Lifang Wang, MD^d,e ; Fuquan Zhang, MDⁱ ; Jianli Yang, MD^j,k ; Keqing Li, MD^l ; Luxian Lv, MD^m ; Qingrong Tan, MDⁿ ; Yinfei Li, MD^a,b ; Hua Yu, MD^a,b ; Hongyan Zhang, MD, PhD^d,e ; Xin Ma, MD^g ; Fude Yang, MD^h ; Lingjiang Li, MD^f ; Qi Chen, MD^o ; Wei Wei, MD^a,b ; Liansheng Zhao, MSc^a,b ; Huiyao Wang, MMed^a,b ; Xiaojing Li, MD^a,b ; Wanjun Guo, MD^a,b ; Xun Hu, PhD^p ; Yang Tian, MSc^a,b ; Hongyan Ren, MD^a,b ; Xiaohong Ma, MD^a,b ; Jeremy Coid, MD^a,b ; Dai Zhang, MD, PhD^d,e ; Tao Li, MD^a,b

Commentary

Inadequate Response to Antidepressant Treatment in Major Depressive Disorder

J Clin Psychiatry 2020;81(3):OT19037COM5

George I. Papakostas, MD^a ; W. Clay Jackson, MD, DipTh^b ; Roueen Rafeyan, MD, DFAPA, FASAM^c ; Madhukar H. Trivedi, MD^d

Commentary

Perspectives on the COVID-19 Pandemic and Individuals With Serious Mental Illness

J Clin Psychiatry 2020;81(3):20com13412

Ann K. Shinn, MD, MPH^a ; Mark Viron, MD^b

Commentary

COVID-19: Humanitarian and Health Care Crisis in a Third World Country

J Clin Psychiatry 2020;81(3):20com13383

Chittaranjan Andrade, MD

Commentary

"What Were You Before the War?" Repurposing Psychiatry During the COVID-19 Pandemic

J Clin Psychiatry 2020;81(3):20com13373

Ginger E. Nicol, MD^a ; Jordan F. Karp, MD^b ; Angela M. Reiersen, MD, MPE^a ; Charles F. Zorumski, MD^a ; Eric J. Lenze, MD^a

Commentary

Keep Socially (but Not Physically) Connected and Carry On: Preventing Suicide in the Age of COVID-19

J Clin Psychiatry 2020;81(3):20com13370

Philippe Courtet, MD, PhD^a,b,c ; Emilie Olié, MD, PhD^a,b,c ; Christophe Debien, MD^d,e ; Guillaume Vaiva, MD, PhD^d,e

Commentary

Psychiatry's Niche Role in the COVID-19 Pandemic

J Clin Psychiatry 2020;81(3):20com13363

Joseph F. Goldberg, MD

Commentary

A Viewpoint From Paris on the COVID-19 Pandemic: A Necessary Turn to Telepsychiatry

J Clin Psychiatry 2020;81(3):20com13361

Emmanuelle Corruble, MD, PhD^a,b

Commentary

COVID-19 Diary From a Psychiatry Department in Italy

J Clin Psychiatry 2020;81(3):20com13357

Andrea Fagiolini, MD^a ; Alessandro Cuomo, MD^a ; Ellen Frank, PhD^b

Commentary

Inclusion of Suicidal Individuals in Research Studies

J Clin Psychiatry 2020;81(3):20com13276

Philippe Courtet, MD, PhD^a,b ; Bénédicte Nobile, PharmD, PhD^a,b

Commentary

Challenges in Determining Outcomes of Prenatal Exposure to Antidepressants

J Clin Psychiatry 2020;81(3):20com13269

Ruta M. Nonacs, MD, PhD^a,* ; Lee S. Cohen, MD^a

Clinical and Practical Psychopharmacology

Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron

J Clin Psychiatry 2020;81(3):20f13472

Chittaranjan Andrade, MD

Clinical and Practical Psychopharmacology

Genes as Unmeasured and Unknown Confounds in Studies of Neurodevelopmental Outcomes After Antidepressant Prescription During Pregnancy

J Clin Psychiatry 2020;81(3):20f13463

Chittaranjan Andrade, MD

ASCP Corner

Antipsychotic Polypharmacy in Schizophrenia: Why Not?

J Clin Psychiatry 2020;81(3):19ac13118

Daniel Guinart, MD^a,b,c ; Christoph U. Correll, MD^a,b,c,d

Letter to the Editor

Behavioral Symptoms Improve Prediction Models of Mortality in Patients With Dementia

J Clin Psychiatry 2020;81(3):19lr13217

Pedro J. Modrego, MD

Letter to the Editor

Dr Cheng and Colleagues Reply

J Clin Psychiatry 2020;81(3):19lr13217a

Chih-Ming Cheng, MD, MD^a,b,c,d ; Mu-Hong Chen, MD, PhD, MD, PhD^a,b,c ; Cheng-Hung Yang, MD, MD^a,b ; Shih-Jen Tsai, MD, MD^a,b ; Chia-Fen Tsai, MD, PhD, MD, PhD^a,b,c

Educational Activity

Patient-Centered Psychopharmacology and Psychosocial Interventions: Treatment Selection and Shared Decision-Making to Enhance Chances for Recovery

J Clin Psychiatry 2020;81(3):MS19053BR4C

John Lauriello, MD

Educational Activity

Current Treatment Options and Emerging Agents for Schizophrenia

J Clin Psychiatry 2020;81(3):MS19053BR3C

Christoph U. Correll, MD

Educational Activity

Using Patient-Centered Assessment in Schizophrenia Care: Defining Recovery and Discussing Concerns and Preferences

J Clin Psychiatry 2020;81(3):MS19053BR2C

Christoph U. Correll, MD^a

Educational Activity

Identifying and Treating Insomnia in Patients Living With Alzheimer's Disease

J Clin Psychiatry 2020;81(3):ME19014WC1C.

Alon Avidan, MD, MPH ; Anna Burke, MD

Educational Activity

Recognizing Inadequate Response in Patients With Major Depressive Disorder

J Clin Psychiatry 2020;81(3):OT19037BR2

W. Clay Jackson, MD, DipTh ; George I. Papakostas, MD ; Roueen Rafeyan, MD, DFAPA, FASAM ; Madhukar H. Trivedi, MD

Educational Activity

Implementing Measurement-Based Care to Determine and Treat Inadequate Response

J Clin Psychiatry 2020;81(3):OT19037BR1

Madhukar H. Trivedi, MD ; George I. Papakostas, MD ; W. Clay Jackson, MD, DipTh ; Roueen Rafeyan, MD, DFAPA, FASAM

Educational Activity

Inadequate Response to Treatment in Major Depressive Disorder: Augmentation and Adjunctive Strategies

J Clin Psychiatry 2020;81(3):OT19037BR3

Roueen Rafeyan, MD, DFAPA, FASAM ; George I. Papakostas, MD ; W. Clay Jackson, MD, DipTh ; Madhukar H. Trivedi, MD

Educational Activity

Overcoming Challenges to Treat Inadequate Response in Major Depressive Disorder

J Clin Psychiatry 2020;81(3):OT19037BR4

George I. Papakostas, MD ; W. Clay Jackson, MD, DipTh ; Roueen Rafeyan, MD, DFAPA, FASAM ; Madhukar H. Trivedi, MD

Volume 81 • 2020 • 3

Editorial

Addressing the Experience of Children and Adolescents During the COVID-19 Pandemic

Consensus Statement

Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie

Meta-Analysis

Effect of Continuing and Discontinuing Medications on Quality of Life After Symptomatic Remission in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Efficacy, Effect on Mood Symptoms, and Safety of Deep Brain Stimulation in Refractory Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Interventions and Transition in Youth at Risk of Psychosis: A Systematic Review and Meta-Analyses

Review Article

Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review

Original Research

Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care: Phase 3, Randomized, Double-Blind, Active-Control ALPINE Study

Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent: Double-Blind, Randomized Study (ASPIRE I)

Contributing Factors to Heterogeneity in the Timing of the Onset of Nonfatal Suicidal Behavior: Results From a Nationally Representative Study

Suicide Attempts Among Pregnant and Postpartum Women in Japan: A Nationwide Retrospective Cohort Study

Efficacy and Safety of Guanfacine Extended-Release in the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Randomized, Double-Blind, Placebo-Controlled Study

Machine Learning Algorithms in Suicide Prevention: Clinician Interpretations as Barriers to Implementation

Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2)

Evaluation of Cardiometabolic Risk in a Large Psychiatric Cohort and Comparison With a Population-Based Sample in Switzerland

Metabolic Effects of 7 Antipsychotics on Patients With Schizophrenia: A Short-Term, Randomized, Open-Label, Multicenter, Pharmacologic Trial

Commentary

Inadequate Response to Antidepressant Treatment in Major Depressive Disorder

Perspectives on the COVID-19 Pandemic and Individuals With Serious Mental Illness

COVID-19: Humanitarian and Health Care Crisis in a Third World Country

"What Were You Before the War?" Repurposing Psychiatry During the COVID-19 Pandemic

Keep Socially (but Not Physically) Connected and Carry On: Preventing Suicide in the Age of COVID-19

Psychiatry's Niche Role in the COVID-19 Pandemic

A Viewpoint From Paris on the COVID-19 Pandemic: A Necessary Turn to Telepsychiatry

COVID-19 Diary From a Psychiatry Department in Italy

Inclusion of Suicidal Individuals in Research Studies

Challenges in Determining Outcomes of Prenatal Exposure to Antidepressants

Clinical and Practical Psychopharmacology

Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron

Genes as Unmeasured and Unknown Confounds in Studies of Neurodevelopmental Outcomes After Antidepressant Prescription During Pregnancy

ASCP Corner

Antipsychotic Polypharmacy in Schizophrenia: Why Not?

Letter to the Editor

Behavioral Symptoms Improve Prediction Models of Mortality in Patients With Dementia

Dr Cheng and Colleagues Reply

Educational Activity

Patient-Centered Psychopharmacology and Psychosocial Interventions: Treatment Selection and Shared Decision-Making to Enhance Chances for Recovery

Current Treatment Options and Emerging Agents for Schizophrenia

Using Patient-Centered Assessment in Schizophrenia Care: Defining Recovery and Discussing Concerns and Preferences

Identifying and Treating Insomnia in Patients Living With Alzheimer's Disease

Recognizing Inadequate Response in Patients With Major Depressive Disorder

Implementing Measurement-Based Care to Determine and Treat Inadequate Response

Inadequate Response to Treatment in Major Depressive Disorder: Augmentation and Adjunctive Strategies

Overcoming Challenges to Treat Inadequate Response in Major Depressive Disorder

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