This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Augmentation Strategies to Increase Antidepressant Efficacy

Richard C. Shelton, MD

Published: August 15, 2007

Article Abstract

Augmentation strategies for the treatment of major depressive disorder (MDD) are needed when patients with MDD have not tolerated or responded to antidepressant monotherapies. Clinicians can employ sequenced treatment steps, preferably coupled with the use of a treatment algorithm, to utilize augmentation strategies that will enable patients to achieve remission. The focus of augmentation therapy has been combining an antidepressant medication with another antidepressant; however, atypical antipsychotics are becoming commonly used to augment antidepressants. Beyond antidepressants and antipsychotics, alternative augmentation strategies include emerging pharmacologic treatments and nonpharmacologic strategies.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 68

Quick Links: