Are Nutritional Supplements Ready for Prime Time?
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Over the past 20 years, there has been a surge of clinical trialsexamining the safety and efficacy of natural compounds forpsychiatric indications. These studies have produced encouragingevidence for several putative antidepressants such asS-adenosyl-L-methionine (SAMe), St. John’s wort (SJW), theomega-3 fatty acids, and folic acid.
There are about 45 published randomized controlled trials(RCTs) of SAMe monotherapy against placebo or tricyclic antidepressants(TCAs).’ ‹
J Clin Psychiatry 2008;69(9):1497-1498
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