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Generalized Anxiety Disorder and Psychiatric Comorbidities Such as Depression, Bipolar Disorder, and Substance Abuse

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Generalized anxiety disorder (GAD) has a high rate of comorbidity with other psychiatric disorders,including major depressive disorder (MDD), bipolar disorder, other anxiety disorders, and substanceuse disorders. The similarities between GAD and MDD have led some to suggest that GADshould be reclassified as a mood disorder. The concurrence of GAD with another disorder heightens apatient’s risk for impairment, disability, and suicidality. Clinical trials for GAD and disorders that aremost likely to occur with GAD have generally not taken comorbidity into account, and there is a paucityof data guiding how comorbidity should inform treatment selection.’ ‹


J Clin Psychiatry 2009;70(suppl 2):10-14

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