This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.

Articles

The Role of Second-Generation Antipsychotic Monotherapy in the Rapid Control of Acute Bipolar Mania

Article Abstract

A key goal of the pharmacologic treatment of acute bipolar mania is rapid symptom improvement.Medications commonly used to attain this goal include lithium, several anticonvulsants, and bothfirst- and second-generation antipsychotics. Second-generation antipsychotics, which are associatedwith substantially lower rates of extrapyramidal side effects than first-generation agents, are becominga mainstay in the treatment of acute mania. Although their efficacy appears to be comparable,second-generation antipsychotics may differ in time to onset and in their side effect profiles. Therefore,selecting a second-generation antipsychotic requires consideration of how an agent’s efficacy,onset of action, and adverse events profile influence its appropriateness for each patient.


Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 66

Quick Links: Bipolar Disorder