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Case Report

A Case of Persistent Genital Arousal Disorder Successfully Treated With Topiramate in a Physically Healthy Individual

Maya Ramic, MD, PhD

Published: July 15, 2013

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Persistent genital arousal disorder (PGAD) was first described in 2001 by Leiblum and NathanIn 2003, it was recognized as a clinical condition by the International Definitions Committeeand characterized by 5 diagnostic criteria as a physical genital arousal that is (1) involuntary and persistent, (2) unresolved with repeated orgasms, (3) unrelated to sexual desire, (4) intrusive and unwanted, and (5) distressing. Limited available literature suggests that PGAD may be related to nervous system dysfunction, and therefore benzodiazepines, anesthetics, and anticonvulsants have been experimentally used to treat the symptoms.

Volume: 74

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