This work may not be copied, distributed, displayed, published, reproduced, transmitted, modified, posted, sold, licensed, or used for commercial purposes. By downloading this file, you are agreeing to the publisher’s Terms & Conditions.


Common Pathways of Depression and Pain

Pedro L. Delgado, MD

Published: August 1, 2004

Article Abstract

Depressive disorders are chronic conditions that produce both emotional and physical symptoms.Increasing evidence suggests that in some patients with depressive disorders a neurodegenerative processmay occur, highlighting the importance of early and aggressive intervention. Serotonin (5-HT)and norepinephrine (NE) neurotransmitter systems influence neuroplasticity in the brain, and both areinvolved in mediating the therapeutic effects of most currently available antidepressants. Some dual-actionantidepressants have been shown to be effective in managing the pain symptoms associatedwith depression. These agents may have advantages over others by treating a wider array of physicalsymptoms. Additionally, these agents may also have a role in modulating neurogenesis and otherneuroplastic changes, thereby leading to more complete recovery in patients suffering from the emotionaland physical symptoms of chronic depression.

Some JCP and PCC articles are available in PDF format only. Please click the PDF link at the top of this page to access the full text.

Related Articles

Volume: 65

Quick Links: